WeNatal For Her clinical study: What the research found about fertility support, energy, mood, and cycle well-being

For so many women, the path to pregnancy begins long before a positive test. It begins in the quiet moments of wondering what your body needs, trying to make sense of cycle changes, looking at labs, adjusting routines, and hoping that all the small steps you are taking are actually making a difference.

At WeNatal, we believe preconception care should feel less overwhelming and more supportive. Fertility is not just about one hormone, one lab marker, or one perfectly timed cycle. It is connected to nutrient status, energy, mood, metabolic health, oxidative stress, hormone health, and the way you feel in your body month after month.

That belief is what inspired WeNatal For Her. We created it to go beyond a standard prenatal and offer comprehensive support for women preparing for pregnancy, with bioavailable nutrients chosen to support reproductive health, whole-body wellness, and the transition from me to we.

We also believe that trust is built through transparency. That is why we partnered with Citruslabs to conduct a clinical study on WeNatal For Her, so we could better understand how women experienced the product over three menstrual cycles and share those findings with our community.

What was the goal of the WeNatal for Her clinical study?

The goal of this study was to evaluate how WeNatal For Her may support blood biomarkers related to female reproductive health, as well as how women felt throughout their cycles while taking the supplement. WeNatal For Her was designed to support nutrient sufficiency, antioxidant pathways, ovarian function, and whole-body reproductive wellness.

In the study, researchers measured 12 blood biomarkers, including vitamin D, vitamin D-3, AMH, estradiol, testosterone, progesterone, FSH, iron, TSH, C-reactive protein, and others. It also evaluated eight questionnaire-based measures related to sexual health and well-being, including energy levels, mood, fatigue levels, fatigue frequency, breast tenderness frequency, bloating frequency, anxiety frequency, and vaginal dryness frequency.

Key finding 1: Vitamin D levels significantly increased

One of the most important objective findings from the study was the statistically significant increase in vitamin D and vitamin D-3 levels by Cycle 3. 

• Vitamin D increased by 27.60%
• Vitamin D-3 increased by 30.84%

These changes were statistically significant, meaning the result is unlikely to be random chance and would likely be reproduced with similar results if the study were repeated.

This finding is especially relevant for women thinking about fertility because vitamin D plays a role in ovarian function, follicular development, immune health, and pregnancy outcomes. Low vitamin D status has also been associated with increased risk of pregnancy complications, including gestational diabetes, hypertensive disorders of pregnancy, preterm birth, low birth weight, and postpartum mood concerns.  Vitamin D deficiency is  commonly seen in individuals with PCOS/PMOS and research is continuing to explore the relationship between vitamin D supplementation and ovarian reserve markers, including AMH, FSH, and antral follicle count.

Key finding 2: Multiple improvements seen as early as Cycle 1

Many women know that the menstrual cycle can affect much more than the timing of a period. Energy, mood, digestion, bloating, anxiety, libido, vaginal comfort, and breast tenderness can all shift throughout the month, and those symptoms can become even more noticeable when you are trying to conceive.

By Cycle 1, participants reported statistically significant improvements in:

• Energy levels
• Mood
• Fatigue levels
• Bloating frequency
• Anxiety frequency
• Vaginal dryness frequency

Energy showed the largest early improvement, increasing by 33.5% in the first cycle.

This is meaningful because participants began experiencing measurable improvements within the first menstrual cycle of daily use, even though the full study period lasted three cycles.

Key finding 3: All eight well-being parameters improved by Cycle 3

By Cycle 3, all eight measured outcomes showed statistically significant improvement from baseline.

Key changes included:

• Mood increased by 44.8%
• Energy increased by 41.8%
• Fatigue levels decreased by 33.6%
• Bloating frequency decreased by 33.2%
• Vaginal dryness frequency decreased by 36.87%

These findings matter because fertility support is not only about biomarkers on a lab report. How someone feels during their cycle can influence daily quality of life, relationship well-being, body awareness, and overall confidence while preparing for pregnancy.

Key finding 4: Participants reported meaningful improvements in well-being, energy, fatigue, and bloating

In addition to biomarker testing and questionnaire scores, the study also asked participants how much they agreed with product-specific statements throughout the study. 

By Cycle 3:

• 84.38% reported improved overall well-being
• 75% reported increased energy
• 75% reported less fatigue
• 71.88% reported less bloating

In addition, participants also reported strong satisfaction with the product experience:

• 87.5% agreed they would like to continue using the product
• 81.3% agreed they would recommend it to friends and family

These participant-reported outcomes are helpful because they capture something that clinical markers alone cannot fully explain: how women actually felt while using the supplement.

Why nutrients and foundational support matter for female fertility

Female fertility is influenced by many interconnected systems, including ovarian function, hormone signaling, inflammation, oxidative stress, thyroid health, metabolic health, and overall nutrient status. 

WeNatal For Her was designed with these foundational pathways in mind. Rather than taking a narrow approach to preconception nutrition, the formula is intended to support the body before pregnancy by helping address nutrient needs that are relevant to reproductive health, cycle well-being, and whole-body resilience.

This is also where lifestyle becomes important. A supplement can help fill nutrient gaps and support foundational pathways, but fertility health is also shaped by blood sugar balance, protein intake, micronutrient density, sleep quality, stress physiology, movement, environmental exposures, and the timing of the menstrual cycle. 

Because this study did not include a structured lifestyle program, the results reflect the use of WeNatal For Her on its own rather than what might be seen as part of a broader fertility-focused nutrition and lifestyle approach.

For women who are trying to conceive, preparing to conceive, or simply wanting more support during their cycles, this type of research helps bridge the gap between what a formula is designed to do and how people experience it in real life.

Study limitations: What to keep in mind

While the results are encouraging, they should be interpreted within the context of the study design. This was a small study with 40 participants, and not all participants completed every assessment.  It was also a single-group trial with no placebo or control group. That means all participants received WeNatal For Her, and there is no comparison group to separate supplement effects from natural hormonal fluctuations, placebo effects, or other lifestyle changes that may have occurred during the study period.

The study did not include structured lifestyle interventions such as personalized nutrition guidance, sleep optimization, stress reduction, or cycle-specific coaching.  This is important because fertility and hormone health are deeply responsive to diet quality, blood sugar balance, sleep, stress, movement, alcohol intake, toxin exposure, and other daily habits. A comprehensive lifestyle intervention alongside supplementation would likely create a greater overall effect, but that was not tested in this trial.

What this means for women preparing for pregnancy

The fertility journey can feel overwhelming, especially when advice is scattered across social media, clinic visits, lab results, and conversations with friends. What this study offers is a more grounded way to look at preconception support. It suggests that targeted supplementation with WeNatal For Her may help support vitamin D status and improve several aspects of menstrual cycle-related well-being over three cycles.

For someone preparing for pregnancy, that can be meaningful because preconception health is not only about a positive pregnancy test. It is also about building nutrient reserves, supporting ovarian health, stabilizing daily energy, feeling more connected to the body, and creating a healthier foundation before conception.

WeNatal For Her is an important foundational tool that can fit into a broader fertility plan, especially for women who want a clinically studied supplement created with reproductive health in mind.

Frequently asked questions about the WeNatal for Her clinical study

What did the WeNatal For Her clinical study measure?

The study measured blood biomarkers related to female fertility and general health, including vitamin D, vitamin D-3, AMH, estradiol, progesterone, FSH, testosterone, iron, TSH, and C-reactive protein. It also measured participant-reported outcomes related to energy, mood, fatigue, bloating, anxiety, breast tenderness, and vaginal dryness.

How long was the WeNatal For Her study?

The study lasted three full menstrual cycles, and participants took three capsules of WeNatal For Her daily with their morning meal throughout the study period.

Did WeNatal for Her improve vitamin D levels?

Yes, vitamin D and vitamin D-3 levels significantly increased by Cycle 3. Vitamin D increased by 27.60 percent, and vitamin D-3 increased by 30.84 percent from baseline.

Did participants feel better during their cycles?

Many participants reported improvements in well-being, energy, fatigue, and bloating by the end of the study. By Cycle 3, 84.38% agreed that their well-being had improved, 75% agreed that their energy had increased, 75% agreed that they had experienced less fatigue, and 71.88% agreed that they had experienced less bloating.

Was this a placebo-controlled clinical trial?

No. This was a single-group clinical trial, which means all participants used WeNatal For Her and there was no placebo or control group. Because of that, the findings are promising but should be interpreted with the understanding that larger, controlled studies are needed.

Did the study include nutrition or lifestyle changes?

No structured lifestyle interventions were included in the study. The results reflect daily use of WeNatal For Her within the trial design, not the combined impact of supplementation plus personalized nutrition, sleep, movement, stress support, or other fertility-focused lifestyle strategies.

A note from WeNatal on our clinical study of WeNatal for Her 

At WeNatal, we know the fertility journey can feel deeply personal. It can also feel overwhelming, especially when you are trying to understand what your body needs and how to feel supported before pregnancy even begins.

These findings are encouraging, and we see them as one early step in better understanding how targeted nutrient support can help women feel more supported before pregnancy. For women preparing for pregnancy, WeNatal For Her offers a clinically studied way to support nutrient status, menstrual cycle well-being, and whole-body preconception health as part of a more comprehensive fertility plan.

To read more about the study and research-back formulation click here. 

If you’re looking for a clear, supportive plan to bring everything together, we created our Complete Preconception Guide as a step-by-step guide designed to help you understand what to focus on, when to focus on it, and how to build a fertility-friendly lifestyle with confidence.

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.